Evolution and development of the mammalian cerebellum

Explore the single nucleus RNA sequencing atlases of the human, mouse and opossum cerebellum, by Kaessmann Lab and Pfister Lab ( Datacommons ), App v1.0






Reference

Mari Sepp*, Kevin Leiss*, Ioannis Sarropoulos, Florent Murat, Konstantin Okonechnikov, Piyush Joshi, Evgeny Leushkin, Noe Mbengue, Céline Schneider, Julia Schmidt, Nils Trost, Lisa Spänig, Peter Giere, Philipp Khaitovich, Steven Lisgo, Miklós Palkovits, Lena M. Kutscher, Simon Anders, Margarida Cardoso-Moreira, Stefan M. Pfister* & Henrik Kaessmann* Cellular development and evolution of the mammalian cerebellum [submitted]

Please see the corresponding app by the Pfister lab (DKFZ, KiTZ) for the analyses of the human data in the context of childhood brain tumors

Methodology

Single nucleus RNA sequencing data were generated from frozen cerebellum samples from human, mouse and opossum at different developmental stages. We used 10x Genomics 3' Chromium protocol (version 2 and 3).

Data & code access

You can download SingleCellExperiment objects using the links below. The data is fully annotated and contains the UMAP and LIGER embeddings.

Human
pre-mRNA | exonic
Mouse
pre-mRNA | exonic
Opossum
pre-mRNA | exonic

Raw sequencing data is available at heiDATA .

The source code of this app can be found here .

Contact

If you have issues or find bugs, please report them via mail or via gitlab.

Furthermore, feel free to contact us via mail: Mari Sepp , Kevin Leiss , Henrik Kaessmann

Data Privacy

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